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Diacetyl-bis(4-methyl-3-thiosemicarbazonato) copperII (CuII(atsm)), an anti-ferroptotic compound that inhibits lipid radical propagation similarly to liproxstatin-1, rather than preventing iron oxidation, and is able to cross the BBB, has shown promising results in phase I PD clinical trials by improving disease severity (211)
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There is no established safe dose, standardized form, or regulatory guarantee for glutathione supplements aimed at joint health, and certain populations including pregnant women and cancer patients require doctor clearance before use
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