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For example, FXR activation can decrease hepatic levels of monounsaturated fatty acids by repressing the expression of stearoyl-coenzyme A desaturase 1 (SCD1), diacylglycerol O -acyltransferase 2 (DGAT2), and lipin 1 (LPIN1), and reduce the liver polyunsaturated fatty acids via decreasing lipid absorption [162]
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