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However, the studies almost always used small sample sizes, often around 10 animals per group, which limits how confidently the results can be applied to people

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However, compounds with an amino acid-based structure (i.e., peptides, proteins, peptidomimetics), including those used in therapeutic applications, have a number of serious limitations, such as conformational instability, short duration of action (short half-life), and insufficient penetration through the blood–brain barrier (BBB) [3,4,5]