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The mechanistic question in Section 2 is whether QA is being cleared into NAD plus or accumulating as a mitochondrial stressor, while Section 3 details how this branch choice rewires NAD plus pools, TCA throughput, and redox ratios at scale [14,94]
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Literature search was conducted on PubMed, Scopus, Web of Science, and Embase using a combination of the keywords gut microbiota, gut microbiome, gut-brain axis, gut-kidney axis, gut-brain-kidney axis, chronic kidney disease, dysbiosis, therapy, metabolites, and neuroinflammation.” Relevant studies were selected and synthesized in this narrative review
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