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Tumor cells acquire Cys indirectly via peripheral glutamine using System X c − as a carrier, SLC7A11 is upregulated in one-third of TNBC cells in vivo , and limiting glutamine uptake or inhibiting System X c − activity increases intracellular ROS levels and slows TNBC metabolism (Timmerman et al., 2013)

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Overall, macrophage polarization is more appropriately understood as the result of metabolic network remodeling, in which glucose metabolism, lipid metabolism, and amino acid metabolism do not operate in isolation, but instead form a highly coupled regulatory system at the levels of metabolic flux direction, signal transduction, and epigenetic regulation