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Comparing our human N-half cryo-EM structure to the reported N-half sections from Thermus filiformis (PDB 8G3H) and Thermus thermophilus HB8 (PDB 8SSC) MetH structures demonstrates how this tight arrangement between the Hcy and THF domains is evolutionarily conserved (Supplementary Fig
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The selenoamino acids are synthesized by plants and microorganisms when Se 2− replaces S 2− in the biosynthetic pathways for sulfur-amino acid synthesis
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