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A complete CoA should include lot number, HPLC purity with method details, mass spectrometry molecular weight confirmation, synthesis and testing dates, appearance, net weight, copper content verification, and storage conditions
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These findings have been confirmed in animal models – ductal constriction or surgical ligation in lambs produces a rapid antenatal remodeling of pulmonary vasculature resulting in increased fetal pulmonary artery pressure and profound hypoxemia after birth, similar to human infants (15,18)
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