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A 2.5–3.0 mm pilot hole is drilled (a 4 mm bone pin is an accepted alternative), after which the dedicated self-tapping femoral cortical screw—its exact diameter is not published, but it measures roughly 6 mm in diameter—threaded in until snug, without over-tightening

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Two other mechanisms were postulated by Esterbauer (1991) and consist in the successive generation of peroxydes and β-cleavage of the lipid chain or as a reaction of acroleine radical with a hydroxyl moiety (exemplification for arachidonic acid in Figure 4, adapted from Esterbauer, 1991)