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Notably, the PtMnIr nanozyme exhibits multiple enzymatic activities, integrating OXD, CAT, SOD, POD, and GPX functionalities, thereby promoting ferroptosis and apoptosis in tumour cells while inhibiting tumour metastasis by establishing an “endogenous GSH consumption–ROS cyclic generation” mechanism [139]

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Supporting this, the NNMT genetic variant rs1941404 has been associated with altered resting energy expenditure in humans [12]