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Recent studies confirm that 1,25(OH) 2 D 3 significantly suppresses NF-κB activation in endometrial inflammation ( 2 D 3 has been shown to inhibit microRNA-mediated regulation of the NF-κB signaling pathway, potentially representing a novel mechanism for inflammatory control ( Figure 2 (B) NLRP3 inflammasome pathway: Vitamin D 3 inhibits NLRP3 activation through dual mechanisms—blocking BRCC3-mediated NLRP3 deubiquitination to prevent complex formation with ASC and Caspase-1