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Adipocyte Metabolism and Function Research Laboratory studies investigate AOD9604’s effects on adipocyte biology: Lipogenesis Inhibition: Examination of de novo lipogenesis suppression, ACC inhibition, FAS expression Fatty Acid Oxidation: Research on β-oxidation enhancement, CPT1 activity, mitochondrial function Adipocyte Differentiation: Studies on preadipocyte differentiation, PPARγ expression, adipogenesis Metabolic Gene Expression: Investigation of transcriptional programs affecting lipid metabolism Inflammatory Markers: Research on cytokine expression, macrophage infiltration, inflammatory signaling Experimental models include 3T3-L1 adipocyte differentiation, primary adipocyte cultures, and adipose tissue explants
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doi: 10.1210/endo-128-4-1857 70 JanvierSCheynsKCanfynMGoscinnySDe SpiegeleerBVanheeCet al
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