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Taken together, the pharmacological results are consistent and mechanistically coherent: in obese mice, a selective NNMT inhibitor reduces fat mass and improves metabolic markers, apparently by increasing adipocyte energy expenditure rather than by suppressing appetite
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The Clustal omega program was employed to perform protein sequence alignment ( Phylogenetic trees were constructed in MEGA 11, by the Neighbor-joining method using 1000 bootstraps as the phylogeny test for Gpx proteins, and by the Maximum Likelihood method using 500 bootstraps as the phylogeny test for Gst proteins
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