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Hepatic mitoribosome abnormalities enhance glucose partitioning towards glycolytic flux and lactate production, which leads to T cell exhaustion and cancer progression
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It proved that molecular events such as the destruction of the membrane potential of mitochondria, downregulation of the activity of protein complexes I, III, and V, and thus the impairment of the ATP generation accompany the process of unbalancing the Bcl-2 family members’ expression [67,68]
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