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Ozempic (semaglutide) is a GLP-1 receptor agonist administered subcutaneously for type 2 diabetes management Bubbles form when medication is injected too superficially, the needle is withdrawn too quickly, or injection sites are not properly rotated Most lumps are benign and resolve as semaglutide is absorbed systemically over several days Seek medical attention if lumps persist beyond one week, become painful or infected, or are accompanied by systemic symptoms Prevention requires proper site rotation (spacing injections 1–2cm apart), holding the needle in place for at least six seconds after injection, and using correct 90-degree angle technique Report persistent side effects to your healthcare professional or via the MHRA Yellow Card Scheme Table of Contents What Causes a Bubble Under the Skin After Ozempic Injection