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The miRNA-148/pyruvate dehydrogense kinase (PDK) 4/suppressor of mother against decapentaplegic (SMAD) pathway played a crucial role in alleviating myocardial ischemia–reperfusion (IR) injury, and PDK4 knockdown via miRNA-148 expression reversed these effects, restoring cardiac function and immune balance while enhancing antioxidant activity [190]
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