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4 VEGF-TKI-induced hypertension Across this therapeutic class, hypertension remains the most common cardiovascular toxicity, affecting 10%–60% of treated patients ( The lecture also emphasized the rapid kinetics of VEGF-TKI-induced hypertension: cases of blood pressure exceeding 180 mmHg may occur within the first day of lenvatinib initiation, with reversal upon treatment interruption ( From a cardio-oncology standpoint, however, the emphasis should be on rapidly optimizing antihypertensive regimens rather than compromising oncologic efficacy through premature dose reductions ( The highest predictors of who will develop VEGF-induced hypertension include those with pre-existing hypertension