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The consequence of its deficiency results in increased stress conditions, which is the basis of the pathophysiology of many organ or tissue-specific diseases such as inflammation, virus infections (HIV), sickle cell anemia, cancer, diabetes, heart attack, stroke, liver disease, cystic fibrosis, Alzheimer’s, and Parkinson’s disease [17,18]
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The model advanced by Baar and colleagues ( Cell , 2017, volume 169) proposed that FOXO4 binds p53 and helps retain it in nuclear foci in senescent cells, and that this sequestration is part of why those cells remain viable
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