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The outcomes of both studies evidenced the inhibition of enzyme activity in the in vitro tests, whereas an increase in enzyme activity was observed in the in vivo tests
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Forced expression of ERR gamma in cardiomyocytes and transgenic overexpression in mouse heart both induced hypertrophic phenotypes, acting through direct transcriptional activation of GATA4 (a Journal of Molecular and Cellular Cardiology study showing that estrogen-related receptor gamma induces cardiac hypertrophy by directly activating the GATA4 promoter in cardiomyocytes and animal models)
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