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Since it is harmless to the human body and can effectively regulate the physiological rhythm of the colon, it is widely used to treat constipation in the elderly, pregnant women, and children
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In our own study we were able to show that LIF mRNA expression was up-regulated very early mainly during the first 3 weeks of cuprizone administration in both CC and cortex thereafter decreasing to normal levels in the recovery phase after toxin withdrawal (Gudi et al., 2011)
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