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Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks
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Epinephrine Addition: The inclusion of Epinephrine helps to constrict blood vessels at the site of administration, thereby prolonging the anesthetic effect of Bupivacaine and reducing systemic absorption, which enhances the action and safety profile
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