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12-week to 48-week Parallel-Arm Design Trials in Adults The program for persistent asthma in adult patients included one 12-week (Trial 1), two replicate 24-week (Trials 2 and 3), and two replicate 48-week (Trials 4 and 5) randomized, double-blind, placebo-controlled trials in a total of 3,476 asthma patients (673 receiving SPIRIVA RESPIMAT 2.5 mcg once-daily, 1,128 receiving SPIRIVA RESPIMAT 5 mcg once-daily, 541 receiving salmeterol 50 mcg twice daily, and 1,134 receiving placebo) on background treatment of at least ICS
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