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In fact, we have previously validated a mathematical model (Immunity Clock) based on immune function parameters (chemotaxis of neutrophils and lymphocytes, neutrophil phagocytosis, natural killer activity, and phytohemagglutinin-stimulated lymphoproliferation) to quantify the rate of aging or biological age in humans, which we have called ImmunolAge [24]
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Particularly, there’s a need for validated human-based models that can recapitulate aspects of human pathophysiology and complement findings from animal studies
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