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Figure 2 2.1 Biology and etiology MSI can generate a cascade of genomic alterations, particularly when insertions or deletions occur within the coding sequences of key regulatory genes, resulting in frameshift mutations ( + cytotoxic T lymphocytes and helper T cells, and they often exhibit tertiary lymphoid structures within or adjacent to the tumor mass

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None of them experienced worsened symptoms or lack of effect, making prolotherapy one of the modalities with the highest reported success rate in that cohort