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The endogenous antioxidant enzymatic system has evolved to control the detrimental effects of free radicals in the ear, including increased levels of antioxidant enzymes, such as copper/zinc and manganese superoxide dismutases (SOD1 and SOD2, respectively), catalase, GSH-related enzymes (glutathione peroxidases (GPxs), glutathione transferases (GSTs), and glutathione reductase), and peroxiredoxins (PRDXs)
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The rate-limiting step for glycine synthesis occurs earlier in the pathway prior to serine synthesis
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