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[DOI] [PMC free article] [PubMed] [Google Scholar] [93].Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE, Intestinal microbiota determine severity of myocardial infarction in rats, FASEB J 26(4) (2012) 1727–35
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Moreover, despite the considerable pre-clinical efficacy of several pharmacological agents targeting pathological events of hemorrhagic stroke, they failed to perform in clinical trials as factors such as the short half-life periods of agents and the role of the blood-brain barrier (BBB) complicated the scenario (Shen et al., 2020)
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