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Human disease involves interacting processes including amyloid and tau pathology, neuroinflammation, vascular factors, aging, genetics, and neuronal dysfunction
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In contrast, the 2,3-diamino substitution in the 1MQ scaffold (2,3-diamino-1MQ) displayed high passive permeability (Table 4), but moderate bi-directional active transport with moderate efflux ratio (Table 5)
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