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Key Takeaway: Glutathione supports skin brightening by inhibiting the enzymes that produce dark pigment and encouraging the body to favor lighter pigment pathways

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Glutamine-derived glutamate efflux was measured by washing cells grown to confluence in 35 mm dishes twice with BME, and incubating them in supplemented BME with 1% dialyzed FCS and 1 mM [ 13 C-5] l-glutamine in the presence or absence of l-GPNA (3 mM) and erastin (10 μM) at 37 °C