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Furthermore, lipid nanoformulation with helper lipids [e.g., cholesterol, dioleoylphosphatidylethanolamine (DOPE), dioleoylphosphocholine (DOPC), distearoylphosphatidylcholine (DSPC), and 1,2-Dimyristoyl-rac-glycerol (DMG-PEG) can further enhance the delivery efficacy by providing shielding effects and thus, stability against RNases and endonucleases within the cytosol and plasma membrane [103]
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