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In general, shorter affinity tags (peptides) are more attractive as they are less likely to interfere with the expression, structure and function of the target protein, and their removal can be exempt, decreasing thus the overall costs of the purification process (Hearn and Acosta, 2001, Hedhammar et al., 2005, Terpe, 2003)

but also helps them get to market faster and simplify regulatory challenges.