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In contrast, chronic iron chelation in vivo , where cells are subject to tighter metabolic constraints, may unintentionally restrict iron availability necessary for mitochondrial energy production
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Specifically in females, RG2833 treatment upregulated immediate early genes such as Arc , Egr1 , and c-Fos , and other genes that participate in memory consolidation and synaptic plasticity (Ndukwe et al., 2025)
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