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Not only is TGFβΞ² essential for maintenance of articular cartilage metabolic and structural homeostasis through regulating the expression of collagen type II and MMP13, the TGFβΞ² signaling also seems to mediate Smad2/3 to facilitate osteoclastic differentiation and bone resorption, recruit nestin-positive MSCs and osteoprogenitors to resorption pits in subchondral bone, and promote osteoblast terminal maturation, depositing extracellular matrix components Col1 and osteocalcin in bone [117,122-124]
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Presentation::20 ampoules x 5ml
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