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With the P493-6 B cell line, an LCL that expresses a conditional 4HT-responsive EBNA2 allele and also carries a heterologous MYC allele controlled by a Tet-OFF promoter (Schuhmacher et al., 2001), we found that re-expression of MYC was sufficient to restore MTHFD2 expression upon EBNA2 inactivation by 4HT withdrawal (Figure 2I) and observed that MTHFD2 and MYC levels were closely correlated
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