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3 An increase in inflammation among individuals living in Western societies is evidenced by the alarming rise of allergy and autoimmune disease in the United States and other Westernized countries over the past century and can be attributed to five major causes that result directly from social and cultural changes: (a) an “inflammatory diet” high in fat and simple sugars and low in fiber and nutrients, (b) lack of physical exercise, (c) chronic and unrequited psychological stress, (d) vitamin D deficiency, and (e) biome depletion

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Reference materials for tissue-matrix research