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2 Given the key role of macrophages in atherosclerotic initiation, progression, and resolution, nanoparticle (NP)-based imaging modalities specifically targeting macrophages, as novel diagnostic and therapeutic strategies, are used to therapeutically manipulate macrophages in the plaques to increase plaque stability and to reduce the risk of cardiovascular disease

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Common biological features of chronic injury Microvascular limitation: the tissue is under-perfused, which slows nutrient delivery and waste removal Inflammatory persistence: cytokine signaling stays elevated and disrupts remodeling Disorganized collagen: collagen exists, but it is poorly aligned, weak, or prone to reinjury Mechanical mismatch: loads exceed tissue capacity due to weakness, compensation, or instability Neurogenic sensitivity: irritated tissues and nerves amplify pain signals even when imaging is “normal” In other words, chronic injuries do not usually need one intervention