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We discuss both cuprizone-induced oligodendrocyte-intrinsic mechanisms of demyelination and oligodendrocyte-extrinsic factors that can induce or exacerbate oligodendrocyte toxicity, with a focus on extrinsic immune-derived factors
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Preexisting conditions may also be tested to ensure facial palsy is not a symptom of something more serious, including Lyme disease, brain tumor or diabetes
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