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There are a number of studies documenting healing of aphthous ulcers using oral B12 as a topical treatment regardless of serum B12 levels
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In addition, there is a hybrid receptor with components of the IR (one α and one β-chain) and the IGF-1R (one α and one β-chain), to which both insulin and IGF-1 can bind to, but with less affinity than that of their putative receptors [98–100]
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