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Furthermore, we demonstrate that R-loop-mediated replication stress induced by HRASV12, but not by cyclin E1, is largely driven by ROS in a manner dependent on PRDX2 and is linked to PRDX2-mediated release of the fork acceleration factor TIMELESS from the replication fork
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This review focuses on specific categories of environmental toxins most strongly implicated in human cancers, including industrial chemicals, pesticides, and persistent organic pollutants
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