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The transcriptome of liver from doxycycline-treated and vehicle control–treated rats revealed 3,224 differentially expressed genes (Figure 6F)
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To directly detect such an inhibition, we used a gsh1 Δ strain and confirmed that exposure to Cd 2+ or Met markedly reduces GSH degradation (supplemental information, Part 6), whereas H 2 O 2 has no measurable effect on GSH recycling (supplemental information, Part 7)
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