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A significant limitation of HDX-MS is its poor resolution and while HDX occurs for every amino acid except proline, exchange rates are evaluated by MS as time-dependent mass shifts in proteolytically cleaved peptides
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In sum, in two large independent cohorts of patients with stable CHD, lower levels of GDF11+MSTN were associated with notably higher rates of incident cardiovascular events and all-cause deaths as well as higher prevalence of LVH
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