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In agreement with the above, altered energy metabolism in the brain correlates with increased ER stress, impaired protein degradation pathways, altered proteostasis, and the accumulation of toxic protein products in the brain (393, 394)
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That said, your doctor can help with prior authorizations, appeals, peer-to-peer reviews, patient assistance programs, and support from foundations, so speak up if thatβs the case, says Afzali
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