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Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases

272 Gavage of Guizhi Paeoniae Zhimu Tang was able to inhibit DNA methyltransferase DNMT3B, reduce the level of CpG methylation in the promoter region of the PI3K gene, lift the episodic silencing, promote PI3K transcription and AKT/mTOR signaling activation, and enhance the autophagy of chondrocytes, as well as reduce the detachment of the cartilage layer and the loss of chondrocytes, and decrease the expression of pro-inflammatory factors at the detachment site, with a marked improvement in the pathologic morphology, and a significant improvement in the KOA symptoms were significantly relieved

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[DOI] [PMC free article] [PubMed] [Google Scholar] [84].Vasa-Nicotera M, Brouilette S, Mangino M, Thompson JR, Braund P, Clemitson J-R, Mason A, Bodycote CL, Raleigh SM, Louis E, Samani NJ, Mapping of a major locus that determines telomere length in humans, Am