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Earlier studies indicate that abnormal activation of the HGF/c-MET signaling pathway may hinder T-cell activation and growth, adversely affect DCs, and enhance the infiltration of immunosuppressive cells (M2-type TAMs, MDSCs, and Tregs), leading to reduced effectiveness of ICIs
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[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Matsubara N, Naito Y, Sasaki M, Yamamoto N, Takahashi S, Uemura H
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