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Due to the unique characteristics of the studied population - individuals infected before completing vaccination and prior to the Omicron variants - it is not feasible to increase the sample size
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Further, methionine adenosyltransferase, MAT1A is expressed predominantly in the adult liver but observably decrease in LIHC patients, implying an elevation of methionine levels and a reduction of SAM levels in LIHC cells [57, 109]
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